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The aim of this research wa s to formulate mangosteen ( Garcinia mangostana L .) pericarp extract into oil-in-water ( O/W ) cream which stable and durable. In order to improve the shelf life durability of the formula, the irradiation of formula using gamma rays from cobalt-60 was done. The concentrations of extract w ere varied to 1 , 2 and 3% and were irradiated by gamma rays with doses of 5, 7.5 and 10 kGy. P hysic ochemical and microbiological properties of these formulas were carri ed out for 90 days stored at 30 ± 2°C and 40 ± 2°C . It was found that both of physicochemical and microbiological properties of the formula s were changed by extract concentration s and after irradiation. The irradiated formulas with dose up to 7.5 kGy, which were stored at 30 ± 2°C and 40 ± 2°C, presented acceptable physicochemical and microbiological stability for at least 90 days. Analysis by  TLC (Thin Layer Chromatograph y )-densitometry to study decomposition of G. mangostana pericarp extract cream formulas was carried out 24 h after preparation and 90 day after storage. The result of TLC-densitometry analysis showed that G. mangostana pericarp extract in the cream formulas did not develop e significant decomposition after 90 day s of storage. Decontamination dose for all formula s was found to be about 7.5 kGy . At this condition, the bacteria and mold-yeast have been killed, without reducing the antioxidant activity. Received: 24 November 2013; Revised: 20 December 2013; Accepted: 26 December 2013

Formulation of Oil-in-Water Cream from Mangosteen (<em>Garcinia mangostana L.</em>) Pericarp Extract Preserved by Gamma Irradiation