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Objective: To compare the effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction. Material and methods: Prospective randomized, parallel, single-blind clinical assay, was developed in the Clinica Estomatologica of Universidad Alas Peruanas Filial Trujillo (Peru). Patients who required a simple extraction by dental caries, were randomized into three groups: 30 received naproxen sodium 550 mg preoperatively and then every 12 hours, 30 received naproxen sodium 550 mg postoperatively and then every 12 hours, and 30, ibuprofen (control group) 400 mg postoperatively and then every 8 hours, according to the established criteria. The procedure was standardized and the analgesic efficacy assessed by visual analog scale, and the presence of adverse drug reactions. Data were analyzed by IBM SPSS Statistics 22, using ANOVA and Duncan test, considering a significance level of 5%. Result: continued therapy with naproxen sodium showed higher analgesic effectiveness at 1, 8 and 24 hours (p<0,05) post simple extraction. Conclusion: continued therapy with naproxen sodium showed greater effectiveness than prophylactic therapy post simple extraction.

Analgesic effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction.