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Diabetic retinopathy is the most common diabetic eye disease leading to vision loss. Disturbances have been detected in many aspects of ocular circulation in diabetes. However, hemodynamic and vessel architectural modulation have not been extensively investigated in DR. Therefore, an objective test for the early diagnosis, progression and therapeutic evaluation of DR based on vascular remodeling may aid to identify the individuals at great risk for visionthreatening problems. In this paper, we present a methodology to characterize the microvascular network structure in diabetic individuals. Our preliminary results may pave the path towards effective monitoring of vessel architecture modulation in diabetic retinopathy.

Quantification of the retinal vascular network structure: towards effective monitoring of vessel architecture modulation in diabetic retinopathy