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Y-chromosome short tandem repeat (STR) analysis is an important tool in forensic casework, especially in sexual assault cases. As Y-STR genetic profiles might be shared and compared between different laboratories, states and even countries, concordance of allele calls among commercial kits is an important consideration. In this work, we investigated the concordance of allele calls in twelve Y-chromosome STR loci (DYS19, DYS385, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439) between the Investigator Argus Y-12 QS (Qiagen) and the AmpFlSTR Yfiler (Life Technologies) kits in a sample of 155 male blood donors from Brasília, Federal District, Brazil. 155 samples previously typed with the YfilerTM kit [Forensic Sci. Int. Genet. S18724973 (2013) 139-73] were also typed with the Investigator Argus Y-12 QS kit. A total of 152 different haplotypes were observed with the YfilerTM kit, 149 being unique and three observed twice, while 145 different haplotypes were obtained with Argus Y-12, 135 being unique and ten observed twice in the population studied. A Different allele call was observed in only one sample at the DYS385 locus as 14-17 using the YfilerTM kit and as 14-16.3 when using Argus Y-12. Haplotype diversity (HD) was calculated as 0.9992 for the results with the Investigator Argus Y-12 and as 0.9997 for the results with YfilerTM. Data obtained demonstrates that apart from the minor differences observed, both kits yielded concordant results for the Brazilian population analyzed.

Concordance Study Between the Investigator Argus Y-12 QS and the AmpFISTR® YfilerTM Kits in a Brazilian Population Sample