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Down syndrome (DS) is a chromosomal disorder that has a specific and highly complex cognitive and behavioral phenotype. Objectives: To study the degree of variability cognitvo profile through neuropsychological diagnostic tests into two distinct developmental ages : aulta school age and older . Participants and Methods: 105 subjects aged child and adult , 43 with and 62 without SD SD were studied. Neuropsychological variables were assessed . Comparative study of different neuropsychological variables between SD and comparison groups was performed , and between groups of children and adults. Results: Children and adult SD neuropsychological performance groups had significantly (p < 0.05) lower than the control groups . 84% of the neuropsychological variables studied in child SD group showed a significant degree of variability ( p < 0.05 ) in the SD group showed adult 44% of the studied variables with a significant degree of variability. Conclusions: The neuropsychological performance in all cognitive deficit in study areas with different levels of representation according to cognitive function, and with a high degree of cognitive variability, especially in childhood.

VARIABILIDAD DEL PERFIL COGNITIVO EN ESCOLARES Y ADULTOS CON SÍNDROME DE DOWN