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Androgen Insensitivity Syndrome (AIS) is a rare hormonal condition associated with disorders of sexual development resulting in a variable phenotype. The AIS is classified in Partial Androgen Insensitivity (PAIS) and Complete Insensitivity to Androgens (CAIS). Hair loss in the female model, also known as Female Androgenetic Alopecia (FPHL), has usually been considered an androgen-dependent disorder that represents the female counterpart of male pattern baldness. However, most women with FPHL have no other signs or symptoms of hyperandrogenism and have normal androgen levels, indicating that our understanding of the pathogenesis of the disorder remains incomplete. We describe a female phenotypic-type hair loss that occurs in a patient with Complete Androgen Insensitivity Syndrome (CAIS) characterized by a 5-alpha-reductase 2 steroid deficiency, in which we performed a non-hormonal combined restorative hair therapy. (Low Laser/Led Light+local sub-dermal infiltration of hair growth factor) and topical minoxidil 5%, which led to an excellent result in hair regrowth after 6 months. In light of these new data, an alternative potential androgen-independent mechanism for FPHL phenotype deserves to be carefully considered, as well as rethinking the identifying term of this type of baldness, in estrogenetic alopecia.

A Case of Hair Regrowth in a Patient with Complete Androgen Insensitivity Syndrome and Female Pattern Hair Loss