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Galactomyces Ferment Filtrate (GFF, PiteraTM) is a yeast derived extract used as a moisturizing agent in cosmetics. GFF demonstrates anti-aging, barrier health, and putative hypopigmenting effects in skin, prompting vitiligo therapeutic potential; thus, the antioxidant properties of GFF are the focus of our study. Foreskin derived Normal Human Epidermal Melanocytes (NHEM) were treated with 0-10% GFF. Cell viability was determined by MTT assay. Reactive Oxygen Species (ROS) were assessed by fluorescent microscopy and luminescence. The mRNA and protein expression were quantitated by RNA-seq transcriptome profiling and Western blot analyses, respectively. GFF sustained cell viability and combated ROS generation in NHEM challenged with 4-Tertiary Butylphenol (4TBP). GFF also suppressed Hydrogen Peroxide (H2O2) generation in NHEM irradiated with Ultraviolet-B (UVB). RNA-seq and Western blot analyses revealed that GFF significantly altered the mRNA and protein levels of phase II antioxidant enzymes (HO1, NQO1, TXNRD1) mediated by nuclear factor, erythroid 2-like 2 (Nrf2)-Antioxidant Response Element (ARE) pathway. HO1 was highly inducible in both the cytoplasm and nucleus in NHEM (6and 8-fold). Altogether, GFF effectively suppresses the generation of ROS in part by up regulating the endogenous levels of antioxidant enzymes via activating the Nrf2-ARE pathway; thus, priming and protecting NHEM against oxidative assaults.

journal of clinical and cosmetic dermatology

Galactomyces Ferment Filtrate Suppresses Reactive Oxygen Species Generation and Promotes Cellular Redox Balance in Human Melanocytes via Nrf2-ARE Pathway