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Background: Aging of the face is characterized by different phenomena happening at more or less the same time, these issues can be addressed both surgically and non surgically, with nonsurgical cosmetic medicine being exponentially more popular than surgical intervention. In this article, authors evaluate efficacy, safety and patient’s satisfaction of a 3 different reticulated HA filler of 15 mg/ml, 20 mg/ml and 25 mg/ml of non animal origin, produced via bacterial fermentation injected in different areas and different plane of the face. Material and methods: Between January 2017 and June 2017, 25 patients (22 female and 3 male), ranging between 27 and 58 years old, seeking facial aesthetic medical treatments were enrolled in the present study. Three different HA filler formulation were used based on the anatomical area to treat: a 15 mg/ml formulation was used to treat crow’s feet and glabella’s wrinkle with superficial/intradermic injections, a 20 mg/ml nasolabial groove and peri-oral wrinkles filling with deep dermal plane injections, a 25 mg/ml to perform non surgical reshape of the nose, malar and chin augmentation with deep bolus injections, next or under the periosteum. Results: Every patient was treated in a single stage injection. In 7 patients an ecchymosis occurred on site injection and was self resolved within 10 days, others complications did not occurred. Patient’s satisfaction form revealed a rating of 7,84/10 after the first month, a 7,2/10 after 3 months and 6,16/10 after 6 months. Conclusions: The HA fillers used in this paper showed a good profile of safety and a different lasting results based not only on the concentration of HA per vial but also due to site injection, deep versus superficial.

Evaluation of Different Depth Injections of Reticulated Hyaluronic Acid Fillers with Different Concentration