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Photoaging is the result of the combination of chronologic aging and the exposition to several extrinsic agents that trigger oxidative stress. It is characterized by dermal and epidermal alterations, such as wrinkles, dryness, sagging, roughness and pigmentary changes. Some of these signs are the result of an impairment of the Extracellular Matrix (ECM) components, which represent the structural and functional dermal support in healthy skin, but are diminished or dysfunctional in aged skin. The aim of the study was to determine the antiaging effects of a new cosmetic treatment formulated with a combination of the Secretion of Cryptomphalus aspersa (SCA), Vitamin C and proteoglycans. 20 Caucasian and 20 Asian female subjects with mild to moderate photoaging were included in the study, and applied the cosmetic product twice daily on the face for 30 days. To assess its antiaging efficacy, clinical evaluation and instrumental determinations were performed at baseline, 15 days and 30 days. Skin moisturization, skin brightness, skin firmness and elasticity, and wrinkle depth were evaluated. The results showed a significant improvement of all these parameters as soon as 15 days after starting the treatment, which was maintained or, in some cases, increased at the end of the study period. In addition, excellent tolerance was referred by all the patients. Due to the fast effects achieved with this new cosmeceutical product for the global improvement of the main signs of photoaging, it could be indicated as an intensive treatment of this condition.

journal of clinical and cosmetic dermatology

Evaluation of the Efficacy of a New Intensive Antiaging Treatment Based on the Combination of the Secretion of Cryptomphalus aspersa, Vitamin C and Proteoglycans