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All over the world, seasonal outbreaks of viral diseases are dependent on rain, temperature, abundance of vector and amplifying hosts, water source, personal hygiene awareness, sanitation status and many more including the remote location. For patient, reaching the rural or primary level health system and getting accurate diagnosis is difficult even in developed countries. In countries with lesser health sources, clinical support and infrastructure for diagnosis as well as the economical condition of the patient affect the outcome and spread of the outbreak. In seasonal outbreaks all over the world each year, a set of similar clinical symptom patterns are detected in majority cases [1]. Multiple etiological agents have been detected [2] and in many cases, they remain undiagnosed [3]. In addition, in few similar clinical symptoms due to concurrent subclinical infections are also detected [2]. The background immune response in each individual, generated by subclinical infections by same or closely related viruses complicates the clinical presentation, response and diagnosis. A few examples are Dengue (DEN), Japanese Encephalitis (JE), West Nile (WN), Herpes simplex virus (HSV), Enteroviruses (EV), etc [4-8]. The changing environment conditions and rapid travel by patient to and fro from known endemic regions to newer areas also pose a problem in quick accurate diagnosis [8-11]. The problem is more amplified or intensified in severe clinical situations like Acute Encephalitis Syndrome (AES), which has at least 20 causative agents [2,3,7,12]. In India, various regions are known for their regular outbreaks [1]. Controlling few of these using preventive measures, along with vaccine coverage using the available vaccines [13, 14] is possible. Quick diagnosis leads to improving treatment modalities and has reduced few of them Influenza H1N1pmd09 [15]. Diagnosing multiple types of seasonable infectious agents from the sporadic infections at out-patient department (OPD) level or in admitted cases is a humongous load and task, especially on public health hospitals. Current situation of diagnostic methods

View Point: Valuable use of antibody based instead of molecular based techniques for diagnosing seasonal viral outbreaks