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Purpose: In order to determine material toxicity, we treated cells at low concentrations for both short and long time periods, and examined cell death and genotoxic effects. Materials and Methods: CdTe QDs functionalized with carboxyl were evaluated on HeLa cells. To determine cytotoxicity, we treated cells at 0.1 to 1000 ng/mL for 1 and 5 days, and examined cell death and genotoxic effects. Cellular and sub cellular localization of QDs was also studied. Results: Present results demonstrate that CdTe-COOH QDs at high concentrations (1000ng/mL) are cytotoxicin HeLa cells. CdTe-COOH QDs induced apoptosis and necrosis (>100 ng/mL) at 5 days. The in vitro results showed that cells incorporated QDs efficiently. QDs were found in cytoplasm and nucleus and the intensity of fluorescence and cell distribution was in a dose-dependent manner. Present results demonstrated that CdTe-COOH QDs were genotoxic at concentrations higher to 100 ng/mL and when cells were treated for long time periods. Conclusion: The CdTe-COOH QDs used in this study could be used for imaging applications in bio medicine, but only at low concentrations and over short time periods. But additional studies are needed to confirm whether long-term exposure in other experimental model scan lead to increased toxicity.

Cellular Localization and Toxicity Assessment of Cdte-COOH Quantum Dots in Hela Cells