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The biological characteristics and physicochemical properties of quantum dots (QDs) pose new challenges in understanding, predicting, and managing their potential adverse health effects following exposure. The safe use of QDs in biomedicine requires a detailed understanding of their biocompatibility and toxicity. This study evaluates the biocompatibility of maltodextrin coated cadmium sulfide quantum dots in rodents. The in vivo localization of maltodextrin coated cadmium sulfide QDs in tissues was studied under fluorescence microscopy, and their biocompatibility was assessed through a histopathological analysis and biochemical assays. Animals treated daily with 200 μg/Kg of maltodextrin coated cadmium sulfide QDs for either 5 days or 15 days showed a differential presence of quantum dots in their organs. Intense fluorescence was detected in kidney, liver; muscle and brain, with moderate fluoresce detected in intestine, lung, and testis. The histopathological and biochemical analyses showed that QDs were non-toxic for rodents. The in vivo analysis revealed the distribution pattern of QDs and their biocompatibility with all tissues analyzed. The bright green emitting of maltodextrin coated cadmium sulfide QDs suggests they might be used as contrast agents for bio-imaging applications.

Bright Green Emitting Maltodextrin Coated Cadmium Sulfide Quantum Dots as Contrast Agents for Bioimaging: A Biocompatibility Study