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Aim: The study was aimed at evaluating the effects of ethanolic extract of Sesamum indicum seeds on the histology and sperm concentration in ketoconazole induced testicular damage in Wistar rats. Methods: Forty eight (48) adult male Wistar rats were divided into eight (8) Groups of six (6) rats each. Groups 1, 2, 3, 4, 5, 6, 7 and 8 were administered 1 ml of normal saline, 100 mg/kg body weight (bwt) of Ketoconazole only, 500 mg/kg bwt of Ethanolic Extract of Sesamum Indicum (EESI) seeds then100 mg/kg bwt of Ketoconazole,100 mg/kg bwt of Ketoconazole then 250 mg /kg body weight of EESI seeds,100 mg/kg bwt of Ketoconazole then 500 mg/kg bwt of EESI, 100 mg/kg body weight of Ketoconazole then 0.36 mg/kg body weight of Mesterolone, 0.36 mg/kg body weight of Mesterolone, 500 mg/kg body weight of EESI respectively. All administrations were carried out orally once per day. The testes were processed for histopathological and semen analyses. Result: Significant increase in the sperm concentration of rats administered EESI before the administration of ketoconazole and enhancement of the histo-architecture of testicular cells were noted when compared with rats in the control Group and those administered ketoconazole only (p ≤ 0.05). Conclusions: Ethanolic extract of sesamum indicum seeds enhances sperm cell concentration and ameliorates the toxic effects of ketoconazole on the testes by improving the cyto-architecture of the treatment group.

clinical research

Ef﻿fects of Ethanolic Extract of Sesamum Indicum Seeds on the Histology and Sperm Concentration in Ketoconazole-Induced Testicular Damage in Male Wistar Rats

Ef﻿fects of Ethanolic Extract of Sesamum Indicum Seeds on the Histology and Sperm Concentration in Ketoconazole-Induced Testicular Damage in Male Wistar Rats

Effects of Ethanolic Extract of Sesamum Indicum Seeds on the Histology and Sperm Concentration in Ketoconazole-Induced Testicular Damage in Male Wistar Rats