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Personalized attributes of a given neoplasm within a given individual patient attest to the highly specific emergence stage as reflected and further evidenced by patterns of evolution and de-evolution of stem cells and of their immediate progenitor cells. Constitutional determination is an incremental degree of sensitivity as borne out by given variants of histologically evolving carcinomatous types and as further involved by metastatic spread within the body. Determined patterns of constitution are induction phenomena in their own right and further conform to the emergence phase as central to any further instituted dimensions of cell multiplication, growth and spread of the malignant cells. It is in terms of such emerging patterns that constitutional parameters of progression are inherently linked to hierarchically determined systems for further patterned progression and spread of the malignant cells.

The Initial Emergence Phenomenon in Patterned Carcinogenesis in Lung Neoplasia