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Copyright: © 2017 Spengler RN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. which normally proceeds to injury resolution. If this active process fails (failure of resolution of injury), the pro-inflammatory state will persist, or an exaggerated post-traumatic inflammatory response will occur, leading to chronic inflammation. The resultant shift that favors a proinflammatory profile over an anti-inflammatory profile signifies loss of physiological homeostasis and is a harbinger of disease onset that includes the expression of chronic pain. This novel understanding of the role of neuroimmunology in the pathogenesis of brain disorders offers new approaches for pioneering breakthroughs.

Lowering Pathologic TNF Levels Exclusively Within the Brain Rapidly Alleviates Long-Standing Injury-Induced Neural Pathologies