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Background: Inhalable medication devices on the market deliver aerosolized drugs in a turbulent flow, which in complex interaction with oropharyngeal geometry causes the major portion of the drug to deposit locally, while creating significant obstacles for reaching the lower lungs. The unintended deposition of aerosolized medications in the oropharynx is known to have negative effects on oral health. The emergence of numerous new aerosolized medications on the market is very likely to add significantly to the list of side effects. We hypothesized that lamination of the outflow by sequentially subdividing the aerosol flow within the spacer into smaller sub-flows using internal septi of different lengths will improve the delivery of the aerosol to distant targets while reducing its deposition in anterior aspects of the airways, especially in oropharyngeal cavity.

Incoming Flow Lamination Increases the Efficiency of Aerosolized Medication Delivery to 3D Oral Mucosal Tissue Models