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Source of Funding: Self Conflicts of interest: None DOI: 10.16965/ijims.2018.101 These lymphoid and myeloid leukemias are associated with varied systemic involvement such as anemia, splenomegaly, generalized lymphadenopathy and petechial haemorrhagic spots. For this reason, the clinician also requires the basic peripheral blood smear study as a preliminary examination to differentiate the various diseases that overlap the symptomatology of acute leukemia clinically. With this background we examined bone marrow and clinical manifestations for rule out the acute leukaemias in Telangana population. During the 25 months of study a total of 36 cases of leukaemias were studied in the Department of pathology, Kakatiya Medical College, Warangal in collaboration with Lifeline Diagnostics, Hyderabad. Out of 36 cases, 20 cases were AML, 15 cases were ALL and 1 case was mixed phenotypic acute leukaemia. The highest number of cases in the adults belonged to AML (16 cases). In children ALL (13cases) formed the majority of cases followed by AML (4 cases). The most common presentation in the study population followed by splenomegaly (38.8%). Out of the AML cases studied, 13 cases were diagnosed by morphology alone and in 5 cases, cytogenetic study helped in sub typing the cases. Out of the ALL cases studied 5 cases were diagnosed by morphology alone and in 3 Cases, cytogenetic studies confirmed the diagnosis. MPO stain was done on all cases of acute leukaemias and (20 cases) out of these showed positivity favouring a diagnosis of AML. PAS stain was done on all cases, (7 cases) of which showed block positivity favouring a diagnosis of ALL.

ACUTE LEUKAEMIAS ON BONE MARROW EXAMINATION AND CLINICAL MANIFESTATIONS IN THE TELANGANA POPULATION