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Source of Funding: Self Conflicts of interest: None DOI: 10.16965/ijims.2016.124 Cardiovascular disease (CVD) is a main cause of morbidity and mortality worldwide. Its prevention through a healthy lifestyle and appropriate diet is important. Omega-3 polyunsaturated fatty acids (n-3 PUFA) therapy has shown promise in both primary and secondary prevention of CVD. This commentary reviews the nutritional role of n-3 PUFA, including its metabolism and physiological role, comparison to n-6 series PUFA, as well as complications due to deficiency. Clinical use of n-3 PUFA for the prevention and treatment of CVD, recommended intake and potential adverse effects will also be examined. The available scientific evidence suggests that its supplementation and clinical use ranging from 0.4 to 7g/day can provide tangible benefits. However, further studies are required to determine optimal dosing and the relative ratio of docosahexaenoic acid and eicosapentaenoic acid that provides maximal cardio-protection and treatment of CVD.

Prevention of Cardiovascular Disease by Dietary n-3 Fatty Acid