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Corresponding Author: Rasha El-shinety, MD, PhD, Ass. Prof. of Anatomy & Embryology, Alexandria Faculty of Medicine, Director of Project Management Unit, Alexandria University, Egypt. Mobile: 01061230422 E-Mail: rashaelshinety@yahoo.com Background: Insecticides such as lambda-cyhalothrin(LCT), dibenzalacetone (DBA) and heptanone HD are teratogenic substances. Skeleton is one of the organs sensitive to teratogens during the period of organogenesis. Material and methods: This study was conducted on fifty adult female albino mice, divided randomly into four groups: Group I (control group, n= 5 received corn oil orally in adose of 10 mg /kg body weight), group II (LCT group, n=10 received LCT (nano 8%)10, 20 mg /kg body weight for each subgroup), group III (DBA group, n=20, received DBA (main) 10, 20 mg /kg body weight and DBA (nano 8%)) 10,20mg /kg body weight for each subgroup) and group IV (HD group, n=15, received HD (main) 10 mg /kg body weight and HD (nano 8%)) 10,50mg /kg body weight for each subgroup),The calculated treatment dissolved in 1 ml of corn oil by orogastric tube was given to the pregnant mice during the first week of pregnancy (1st, 3rd and 5th day).The delivered live and dead pups were examined externally, then double stained and prepared for skeletal examination by dissecting microscope. Results: All experimental groups showed various anomalies that can be categorized as the following: 1) presence of dead pups and resorption sites 2) macroscopic anomalies in the form of anencephaly, extended forelimb, cranioshisis, macroglossia, lowset ears, lage eye bulge, half body, amelia, internal rotation of forelimb and encephalocele. 3) skeletal anomalies by double staining of fetal skeleton showed incomplete ossification of nasal and interparietal bones, open arch of atlas, incomplete ossification of vertebrae, supernumerary ribs, wavy ribs, incomplete ossification of ribs and sternebrae, incomplete ossification of sternum, incomplete ossification of 5th metacarpal and terminal phalangal bones and incomplete ossification of tarsal , and phalangal bones. Conclusion: Lambda-cyhalothrin, dibenzalacetone and derivatives of heptanone result in numbers of congenital gross and skeletal abnormalities that indicate their teratogenic effect.

Congenital skeletal malformations induced by lambda-cyhalothrin, dibenzalacetone and heptanone derivatives in embryos of albino mice