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Corresponding Author: Dr. Neelesh Kumar Shakya, M.D. Forensic Medicine & Toxicology, Assistant Professor, Department of Forensic Medicine & Toxicology, Integral Institute of Medical Sciences & Research, Integral University, Dasauli, Lucknow (U.P.), India. E-Mail: neelesh.shakya12@gmail.com Background: Valproate is an antiepileptic drug which is also known as 2-propylvaleric acid. Valproic acid is presently the most widely used antiepileptic drug because of its antiepileptic effectiveness in a broad range of seizure types: tonic-clonic, myoclonic, absence and partial seizures. Present work was done to evaluate the gross and histological effect of valproate on fetal mice kidney. Materials and Methods: This study was done in anatomy department of Institute of medical sciences, Banaras Hindu University, Varanasi (U.P.). Single dose of valproate (200mg/kg) was administered intraperitoneally on 8th day of gestation and then fetuses were collected at the 18th day of gestation. Results: Kidney was reduced in size in valproate treated group fetuses as compared to kidney of control group fetuses. On histological examination, distorted developing nephrons and clumping of bowman capsule in developed nephrons were seen. Conclusions: Various authors worked on valproate treated adult mice kidney. There are only few study conducted on kidney of mice fetus. In present study, valproate was found teratogenic at the dose of 200mg/kg so it should be avoided in human pregnancy if possible.

VALPROATE INDUCED NEPHROTOXICITY ON FETAL MICE KIDNEY