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Address for Correspondence: Dr. Supadevi Sundarasamy, P6c2b, La Celeste Apartment, Nethaji Street, Madananthapuram Main Road, Mugalivakkam, Chennai, Tamilnadu-600125, India. E-Mail: supadevi.dr@gmail.com Introduction: There is increased incidence of heart valve diseases in recent years due to life style modifications. The mortality rates in the heart valvular diseases are kept in pace using various modes of treatments. One such treatment is valve replacement surgery. It’s done either by using mechanical valve prosthesis or tissue grafts. The tissue valves prosthesis, harvested from porcine heart are called as xenograft and are increasingly used in valve repair surgeries. In the present scenario, there is less number of systematically analysed literatures available on the comparative anatomy of human and porcine heart valves. Hence this study was carried out to acquire knowledge and to put forth some points to future research works on heart valves. Materials and methods: In this study, 20 formalin fixed porcine and human hearts were procured from slaughter house and cadavers respectively. The morphology and morphometry of mitral valve were observed and analysed using spss software 20 version. All the dependent variables were compared using student t test and independent sample test. Observation and results: it was observed that the mean circumference of the human mitral valve was 82.31mm and that of the porcine was 78.79 mm. The rough zone and clear zone was more prominent in porcine heart valves than the human heart valves. It was observed that the mitral valve of the porcine resembles the human heart valve in morphology and morphometrical values were coinciding to their maximum. Conclusion: The porcine valve resembles human heart valves in morphology and it can be used in designing valve substitutes in replacement surgeries. Porcine valve can also be used as bio-prosthesis by matching the morphometry and by reducing the geometrical difference to their minimum by using any modes of interventional radiology.

COMPARATIVE MORPHOLOGICAL AND MORPHOMETRICAL ANALYSIS OF HUMAN AND PORCINE MITRAL VALVE