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OZET Amac: Ileri evre/rekuren over kanseri nedeniyle sitoreduktif cerrahi ve Hipertermik Intraperitonyal Kemoterapi (HIPEC) uyguladimiz hastalardaki peroperatif morbidite ve mortaliteyi arastirdik. Yontem: Ocak 2016-Aralik 2018 tarihleri arasinda HIPEC uyguladigimiz hastalarin elektronik dosyalari ve takipleri retrospektif olarak incelendi. Bulgular: Nihai patolojisi musinoz apandiks tumoru gelen 1 vaka dislandiginda peritonyal karsinomatozis nedeniyle toplam 18 hastaya ileri cerrahi ve HIPEC uygulandi. Hastalarin ortalama yasi 54,6 (aralik, 22-76 yas) idi. Median preoperatif CA125 degeri 64 U/ml (aralik, 6-4756 U/ml) idi. 3 hasta rekurens nedeniyle, 15 hasta (11 interval, 4 first-look cerrahi) ise primer olarak opere edildi. Hastalarin hepsine peritonektomi proseduru, 4 hastaya ise beraberinde barsak rezeksiyonu uygulandi. Ortalama operasyon suresi 323,5 dakika (aralik, 180- 495 dakika) idi. En sik gozlenen dahili morbidite, kan transfuzyonu (83.3%, 15/18); cerrahi morbidite ise yara yeri enfeksiyonu (%16.6, 3/18) bulundu. Hastalarin ortalama hastanede yatis suresi 10,3 gun (aralik, 5-32 gun) idi. Peroperatif mortalite gozlenmedi. Sonuc: HIPEC, yogun bakim kosullari iyi olan ve multidisipliner kliniklerde uygulandiginda peroperatif ciddi morbidite ve mortaliteye neden olmayan bir yontemdir. Anahtar Sozcukler: HIPEC; Peroperatif; Morbidite. ABSTRACT Objective: We investigated peroperative morbidity and mortality in patients who underwent cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced stage/recurrent ovarian cancer. Methods: Between January 2016 and December 2018, electronic files and follow-up of patients who underwent HIPEC were reviewed retrospectively. Results: After one case of mucinous appendiceal tumor was excluded, a total of 18 patients underwent advanced surgery and HIPEC due to peritoneal carcinomatosis were detected. The mean age of the patients was 54.6 years (range, 22-76 years). The median preoperative CA125 value was 64 U/ml (range 6-4756 U/ ml). Fifteen patients (11 interval surgeries, 4 first-look surgeries) were operated primarily while 3 patients were operated due to recurrent disease. Peritonectomy procedure was performed in all patients and bowel resection was performed in 4 patients. The mean operative time was 323.5 minutes (range, 180-495 minutes). The most common medical morbidity was blood transfusion (83.3%, 15/18) while most common surgical morbidity was wound infection (16.6%, 3/18). The mean length of hospitalization was 10.3 days (range, 5-32 days). No peroperative mortality was observed. Conclusion: HIPEC is a method that does not cause severe morbidity and mortality when well intensive care conditions are applied in multidisciplinary clinics. Keywords: HIPEC; Peroperative; Morbidity.

bozok tıp dergisi

İLERİ EVRE/REKÜREN OVER KANSERİ NEDENİYLE HİPERTERMİK İNTRAPERİTONYAL KEMOTERAPİ (HIPEC) UYGULADIĞIMIZ HASTALARDAKİ PEROPERATİF TECRÜBEMİZ Our peroperative experience in patients who underwent Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced stage/recurrent ovarian cancer