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Regenerative medicine advances hold the potential to drive dramatic progress in the prevention and treatment of individuals with a host of acute and chronic pathologies. Regenerative medicine is “an interdisciplinary field of research and clinical applications focused on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function resulting from any cause, including congenital defects, disease, trauma and ageing” [1]. With return to normal activities of daily living as the ultimate goal of these biological therapies, it is clear that regenerative medicine is tightly intertwined with rehabilitation, which also involves the optimization of function and performance. As regenerative medicine approaches increasingly permeate medical practice, important questions arise about the development of adjunct clinical protocols that will maximize the therapeutic benefit of these technologies: Does the initiation of rehabilitation protocols following transplantation of biological scaffolds or cells enhance or hinder functional efficacy of the technology? If a rehabilitation protocol is initiated following administration of a biological therapy, as is likely to occur in a clinical setting, what is the optimal timing and dosing? Finally, how can basic science discoveries be most efficiently translated such that they may guide the development of targeted rehabilitation programs to promote tissue healing

Emergent themes from Second Annual Symposium on Regenerative Rehabilitation, Pittsburgh, Pennsylvania