English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

. Studies of the adequacy of peritoneal dialysis and  recommendations have assumed that renal and peritoneal clearances are  comparable and therefore additive. The CANUSA data were reanalyzed in an  effort to address this assumption. Among the 680 patients in the original  CANUSA study, 601 had all of the variables of interest for this report.  Adequacy of dialysis was estimated from GFR (mean of renal urea and creatinine  clearance) and from peritoneal creatinine clearance. The Cox  proportional-hazards model was used to evaluate the time-dependent association  of these independent variables with patient survival. For each 5 L/wk per 1.73  m 2  increment in GFR, there was a 12% decrease in the relative risk  (RR) of death (RR, 0.88; 95% confidence interval [CI], 0.83 to 0.94) but no  association with peritoneal creatinine clearance (RR, 1.00; 95% CI, 0.90 to  1.10). Estimates of fluid removal (24-h urine volume, net peritoneal  ultrafiltration, and total fluid removal) then were added to the Cox model.  For a 250-ml increment in urine volume, there was a 36% decrease in the RR of  death (RR, 0.64; 95% CI, 0.51 to 0.80). The association of patient survival  with GFR disappeared (RR, 0.99; 95% CI, 0.94 to 1.04). However, neither net  peritoneal ultrafiltration nor total fluid removal was associated with patient  survival. Although these results may be explained partly, statistically, by  less variability in peritoneal clearance than in GFR, the latter seems to be  physiologically more important than the former. The assumption of equivalence  of peritoneal and renal clearances is not supported by these data.  Recommendations for adequate peritoneal dialysis need to be reevaluated in  light of these observations.

Relative Contribution of Residual Renal Function and Peritoneal Clearance to Adequacy of Dialysis