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There is previously published evidence that male gender  is associated with a more rapid rate of progression of nondiabetic chronic  renal disease. However, some investigators have concluded that no such  association exists. To help resolve this issue, a meta-analysis was performed  using 68 studies that met defined criteria and contained a total of 11,345  patients to evaluate the effect of gender on the progression of nondiabetic  chronic renal disease. The results indicate that men with chronic renal  disease of various etiologies show a more rapid decline in renal function with  time than do women.

Effect of Gender on the Progression of Nondiabetic Renal Disease