Open AccessAlpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black Americans
Author(s) -
A. Parker Ruhl,
Neal Jeffries,
Yu Yang,
Rakhi P. Naik,
Amit Patki,
Lydia H. Pecker,
Bryan T. Mott,
Neil A. Zakai,
Cheryl A. Winkler,
Jeffrey B. Kopp,
Leslie A. Lange,
Marguerite R. Irvin,
Orlando M. Gutierrez,
Mary Cushman,
Hans C. Ackerman
Publication year - 2021
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2021050653
Subject(s) - kidney disease , medicine , copy number variation , incidence (geometry) , cohort , gene , longitudinal study , disease , cohort study , kidney , nephrology , kidney cancer , epidemiology , oncology , alpha (finance) , cancer incidence , negroid , biology , prospective cohort study , immunology , retrospective cohort study , globin , pathology
α -Globin is expressed in endothelial cells of resistance arteries, where it limits endothelial nitric oxide signaling and enhances α -adrenergic-mediated vasoconstriction. α -Globin gene ( HBA) copy number is variable in people of African descent and other populations worldwide. Given the protective effect of nitric oxide in the kidney, we hypothesized that HBA copy number would be associated with kidney disease risk.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom