Open AccessAlpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black Americans
Author(s) -
A. Parker Ruhl,
Neal Jeffries,
Yang Yu,
Rakhi P. Naik,
Amit Patki,
Lydia H. Pecker,
Bryan T. Mott,
Neil A. Zakai,
Cheryl A. Winkler,
Jeffrey B. Kopp,
Leslie A. Lange,
Marguerite R. Irvin,
Orlando M. Gutiérrez,
Mary Cushman,
Hans Ackerman
Publication year - 2022
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2021050653
Subject(s) - kidney disease , medicine , vasoconstriction , endocrinology , hazard ratio , confidence interval
α -Globin is expressed in endothelial cells of resistance arteries, where it limits endothelial nitric oxide signaling and enhances α -adrenergic-mediated vasoconstriction. α -Globin gene ( HBA) copy number is variable in people of African descent and other populations worldwide. Given the protective effect of nitric oxide in the kidney, we hypothesized that HBA copy number would be associated with kidney disease risk.