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Antibodies against phospholipase A 2 receptor 1 (PLA 2 R1) are found in 80% of patients with membranous nephropathy, and previous studies described three autoantibody-targeted PLA 2 R1 epitope regions. Although anti-PLA 2 R1 antibody levels are closely associated with treatment response and disease prognosis, the clinical role of epitope regions targeted by autoantibodies is unclear.

Clinical Relevance of Domain-Specific Phospholipase A2 Receptor 1 Antibody Levels in Patients with Membranous Nephropathy