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The electron microscopic investigation of the rectal mucosa of human fetuses and children revealed the occurrence of two types of basal-granulated cells mainly in the lower half of crypts. By use of the Wiesbaden terminology these cells could be indentified as intestinal enterochromaffin (EC) cells and large granule (L) cells. EC cells were never seen reaching the luminal surface. L cells in the rectum of fetuses tended to have their long axis along the basement membrane and were never seen reaching the lumen, whereas L cells in the rectum of children frequently were observed to reach the luminal surface with a cytoplasmic process.

Ultrastructure of Basal-Granulated Cells in the Rectum of Human Fetuses and Children