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As to the fine structure of the pancreatic islet, numerous papers have been published since the works of LACY (1957 a, b) and FERREIRA (1957). However, there are still some problems concerning the production and extrusion mechanisms of the secretory granules of islet cells, though beautiful schemata have been represented in a few reports. The present authors observed several features showing the meschanism of production and release of the secretory granules in A and B cells. It is well known that the striking hypoglycemia, sometimes the hypoglycemic shock is induced several hours after alloxan treatment. Though several papers have already been published on the fine structure of B cells in alloxan-diabetic animals (WILLIAMSON and LACY 1959, FALKMER and OLSSON 1962, MERLINI and CARAMIA 1965, BURTON and VENSEL 1966 and so on), the relationship between the alloxanhypoglycemia and the fine structural alteration of the cell has not yet been clarified. We have obtained numerous pictures giving some suggestions to solve this problem.

archivum histologicum japonicum

Some Observations on the Fine Structure of the Pancreatic Islet of Rabbits, with Special Reference to B Cell Alteration in the Hypoglycemic State Induced by Alloxan Treatment