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Gonadotrophs immunocytochemically identified with an antibody to LH beta were studied in both male and female rats of various ages, viz., 2, 14 and 23 months after birth. The rat gonadotrophs are classified into two cell types, i.e., Type I containing large (300-700 nm) and small (150-200 nm) secretory granules, and Type II containing only small (100-200 nm) secretory granules. In normal young adults, the male rat pituitary contains a large number of Type I cells (more than 90% of all gonadotrophs), whereas the female pituitary contains much more Type II cells (more than 70%) than Type I cells. With age, Type I gonadotrophs in the male rat pituitary decrease remarkably to less than 25%, while Type II cells constitute more than 70% at the age of 23 months; the ratio of Type I to Type II comes to be the same as in the female. The main cause of this change is the decrease in the number of large secretory granules as the animal ages. FSH and LH levels in both the pituitary and serum were determined by radioimmunoassay. Pituitary FSH content decreased gradually in the male with age, while that in the female showed no change. LH content in the male decreased slowly, but LH in the female increased with aging. The large secretory granules indicating the presence of FSH markedly decreased with aging. The Type II cells contain only small secretory granules which probably contain LH. Thus the results of morphological counting of each type of gonadotroph and those of radioimmunoassay of gonadotropins during aging were essentially parallel. Some signs of degeneration were observed in the gonadotrophs in the aged rat pituitaries.

archives of histology and cytology

Immunoelectron Microscopic Studies of Gonadotrophs in the Male and Female Rat Anterior Pituitaries, with Special Reference to their Changes with Aging.