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In Heteropneustes fossilis, administration of a single dose (0.15 micrograms/g body weight, i.p.) of [D-Ala6,Gly10]-gonadotrophin-releasing hormone analogue (GnRHa) induced ovulation (in 35 of 35 fish) when mild-stripped at 16 h. Plasma gonadotrophin II (GTH II) levels showed a highly significant increase at 2, 4, 8, 12 and 16 h with the peak at 8 h. Plasma cortisol, progesterone and testosterone showed significant elevations at 2, 4, 8 and 12 h with peaks at 8 h (cortisol and testosterone) and 4 h (progesterone). The levels declined to control values at 16 and 48 h except that of testosterone which decreased even further. In contrast, plasma levels of oestradiol-17 beta decreased significantly at 2, 4, 8 and 12 h, with the lowest value at 8 h, but increased at 16 and 18 h. The contents of hypothalamic and pituitary serotonin and noradrenaline increased at 8 h, coinciding with the peak GTH II rise, and decreased at 16 h. In contrast, dopamine content declined at 8 h in both the hypothalamus and pituitary, but increased at 16 h only in the hypothalamus. The hypothalamic adrenaline level decreased at 8 h but increased significantly at 16 h. Hypothalamic levels of monoamine oxidase, catechol O-methyltransferase and dopamine beta-hydroxylase were elevated significantly at 8 h; the dopamine beta-hydroxylase activity decreased at 16 h. Phenylethanolamine N-methyltransferase activity was elevated only at 16 h, coinciding with the rise in adrenaline content. It is inferred that the preovulatory decrease in dopamine content concomitant with rises in serotonin and noradrenaline levels, triggered by the low titre of oestradiol, might have potentiated the GnRHa/GnRH (endogenous)-induced release of GTH II for a prolonged period.

journal of endocrinology/journal of endocrinology

Periovulatory changes in hypothalamic and pituitary monoamines following GnRH analogue treatment in the catfish Heteropneustes fossilis: a study correlating changes in plasma hormone profiles