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The present-day world is threatened by increasing insecurity caused by global disparities and processes of global change. While in Europe, the US, and other countries of the “North” climate change has commonly been perceived as the most problematic component of global change, developing and transition countries are affected by a multitude of environmental, political, economic, socio-cultural, and technical development problems and disparities. These occur in many different contexts, and their frequency and acuteness have greatly increased in the 20th century. The challenge for research that aims to produce knowledge relevant to prevention and mitigation of such problems and disparities is that problems do not occur independently of each other, but are closely interrelated, appearing in clusters. Such clusters of problems can be referred to as “syndromes of global change.” In Switzerland, an important opportunity for funding research in this field arose in 1999. The Swiss Federal Government and Parliament, at the request of the Swiss National Science Foundation (SNSF), introduced a new mechanism to support cutting-edge research. Fourteen National Centres of Competence in Research (NCCRs) were established, with a maximum projected funding period of 12 years. One of the few programs selected from several hundred ideas, nearly 100 pre-proposals, and 34 final full proposals, was the NCCR North–South, entitled “Research Partnerships for Mitigating Syndromes of Global Change.” It is co-financed by the Swiss Agency for Development and Cooperation (SDC) and SNSF (equal funding), as well as by contributions from the 7 Swiss institutions involved. The overall goal of the NCCR North–South is to enhance sustainable development through research partnerships involving institutions within Switzerland and their partners in developing and transition countries. Three long-term objectives have been defined to achieve this goal:

The Mountain and Highland Focus of the Swiss National Centre of Competence in Research (NCCR) North–South