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Adhesion molecules on CD34 +  cells were implicated in the process of peripheral blood stem cell (PBSC) mobilization and homing. We studied the mobilization of CD34 + Thy1 +  cells, CD34 +  very late‐acting antigen (VLA)4 +  cells, and CD34 + L‐selectin +  cells in non‐Hodgkin's lymphoma patients mobilized with cyclophosphamide plus G‐CSF, GM‐CSF, or GM‐CSF followed by G‐CSF. The mean percentage of CD34 +  cells in the bone marrow (BM) expressing Thy1 was 23.6% ± 11% and 17.8% ± 8% in the PB before mobilization, and was markedly decreased to 4.5% ± 3.3% in the apheresis collections. Similarly, the mean percentage of CD34 +  cells expressing L‐selectin was 35.8% ± 4.3% in the BM, 21.6% ± 4.1% in the PB before mobilization and was markedly decreased to 9.1% ± 2.5% in the apheresis collections. Patients in the three arms of the study had a similar pattern of CD34 + Thy1 +  and CD34 + L‐selectin +  cell mobilization. Also, a similar pattern of coexpression of CD34 + Thy1 +  and CD34 + L‐selectin +  cells was observed when the patients were regrouped as “good mobilizers” (≥2 × 10 6  CD34 + CD45 dim  cells/kg, in four collections) and “poor mobilizers” (&lt;0.4 × 10 6  CD34 + CD45 dim  cells/kg, in two collections).  The mean percentage of CD34 +  cells expressing VLA‐4 in the BM and PB was relatively high (73.4% ± 12% and 65.4% ± 6.6%, respectively) and dropped considerably in the PBSC collections to 43.5% ± 7.1% with a similar pattern observed for patients in arms A, B, and C. However, when the patients were regrouped as “good mobilizers” and “poor mobilizers,” a higher percentage of CD34 +  cells expressing VLA‐4 was observed in the PBSC of the pooled “good mobilizers” (50.5% ± 9% versus 36.3% ± 6.4%;  p  = 0.01). We conclude that release of CD34 +  cells to the PB involves a general downregulation of Thy1, L‐selectin and VLA‐4 on CD34 +  cells, irrespective of the growth factor used for mobilization. However, good mobilizers had a relatively higher percentage of CD34 +  cells expressing the VLA‐4 antigen.

Expression of Adhesion Molecules on CD34 + Cells in Peripheral Blood of Non‐Hodgkin's Lymphoma Patients Mobilized with Different Growth Factors