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[ABSTRACT] Chaga (the sclerotia of Inonotus obliquus) has been widely used as a folk medicine in the treatment of cancer, cardiovascular disease and diabetes in Russia, Poland, and several Baltic countries. More recently, this herb has been assessed for its cancer-preventing activity. Using a mouse model of skin cancer, oral administration of Chaga was found to inhibit tumor promotion by 12-O-tetradecanoylphorbol13-acetate following initiation with 7,12-dimethylbenz[a]anthracene in mouse skin.

Inhibitory Effect of Chaga (Inonotus obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis