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ハトムギ (Coix lacryma-jobi L. var. ma-yuen Stapf) は伝統薬として長年用いられ抗腫瘍抗肥満抗糖尿などの機能をもつことが知られているハトムギの子実渋皮薄皮外殻の全ての部分の熱水抽出物の変異原性について検討するために細菌を用いた復帰変異試験マウスリンフォーマ試験およびマウス小核試験を実施したその結果いずれの試験においても陰性の結果が得られ被験食は生体に対し変異原性を有する可能性はないと考えられたCoix lacryma-jobi L. var. ma-yuen Stapf is a grass long been used in traditional medicine as a nourishing food and reported to possess pharmacological effects including anti-tumor, anti-obesity, anti-diabetic, etc. In order to evaluate the possible mutagenicity of the hot water extract of all parts (husks, pellicles, and astringent skin) of the food, we performed a reverse mutation test in bacteria, a mouse lymphoma assay and a mouse micronucleus test. The results of all tests were negative. It was concluded that the extract has no mutagenicity for living bodies

nihon hokan daitai iryou gakkaishi

Mutagenicity Test for Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf -Reverse Mutation Test, Mouse Lymphoma Assay (MLA) and Mouse Micronucleus Test