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肩凝りを強く訴える成人健常者 13 名男性 3 名女性 10 名を対象にアスタキサンチン含有ソフトカプセルの肩凝りに対する効果をオープンラベル法で探索的に検討したアスタキサンチン 3 mg 含有ソフトカプセルを 1 日 2 カプセル4 週間摂取させ被験者アンケートと肩血流量の変化で肩凝りに対する効果を評価したその結果摂取前後の比較で「肩の凝り」「体の疲れ」「いらいら感」「手足の冷え」「眼の疲れ」および「眼のかすみ」の自覚症状で有意な改善が認められたまたレーザードップラー血流画像測定の結果摂取後に有意な血流量の増加がみられた安全性の確認のために摂取前後で血液検査を実施したが臨床上問題となる異常変動はみられずまた試験食品に起因する有害事象も認められなかった以上のことよりアスタキサンチンの摂取により肩血流量が増加しその結果肩凝りなどの自覚症状が改善する可能性が示唆されたAn exploratory open-label human clinical study was performed in healthy adults with shoulder stiffness to evaluate the efficacy of Astaxanthin by means of measuring blood flow change in the shoulders and subjective questionnaires on physical conditions, including alleviation of stiffness before and after treatment. Two capsules containing 3 mg Astaxanthin each (6 mg in total) were administered once daily (6 mg a day) on days 1 to 28 (4 weeks) to 13 patients (3 men/10 women). All patients were assessed for efficacy and the study demonstrated significant improvements in physical conditions such as shoulder stiffness, physical fatigue, sense of mental irritation, sense of coldness in hands and feet, eye fatigue and eye bleariness. Significant increases of blood flow in shoulders were observed at the end of treatment using laser-doppler graphics. Blood tests conducted to confirm safety before and at the end of treatment showed no clinical differences, and no adverse side effects were reported. In conclusion, Astaxanthin appeared to safely alleviate stiff shoulders and improve other physical conditions during a 4-week open-label study

Supplementation Effect of Astaxanthin on Blood Flow and Shoulder Stiffness -A Preliminary Pilot Study-