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Successful Treatment of Severe Friction Melanosis with Coix-seed Reactive Derivatives (CRD): A Case Report Nobutaka SUZUKI, Hayato SUGIMOTO, Shintaro HASHIMOTO, Hoko KYO, Kazuo UEBABA Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of MedicalScience Sugimoto Orthopedic Clinic Daimyomachi skin Clinic Urata Clinic, Hospy Medical Association Teikyo Heisei University Friction melanosis is a cutaneous entity characterized by a brownish pigmentation distributed on the skin over bony regions of various sites including a trunk or the limbs, after the use, for many years, of a nylon towel or scrub brush to clean the skin. Moreover, repeated trauma due to friction of clothes on the skin over bony prominences are another factors characterizing its pathogenesis. In this report, we presented the case of a 58-year-old man who developed severe friction melanosis around both knees and lower extremities for about 20 years. Coix-seed Reactive Derivatives (CRD) was administrated orally 2.1g twice a day for 6 months. The lesions of pigmentation diminished markedly within 3 months. Further research is needed to define the optimal dose and duration of CRD intake against friction melanosis.