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Fucoidan, a sulfated polysaccharide extracted from various brown alga, such as Kombu, Wakame, and Mozuku, has a complex chemical structure composed of partially sulfated fucose as the major sugar and other sugars, including mannose, galactose, xylose, and uronic acid. Recent studies have reported that fucoidan structure and content differ according to origins of the algae. Gagome kombu (Kjellmaniella crassifolia ) is an edible brown seaweed grown around the southern area of Hokkaido, Japan and contains an abundance of fucoidan. Sakai et al. isolated fucoidan-degrading enzymes from marine bacteria and identified the chemical structure of fucoidan from Gagome kombu (GKF) by nuclear magnetic resonance imaging and mass spectrometry analyses of enzymatic degradation products. Structural analysis revealed that GKF is a polysaccharide that is more sulfated compared with those from other brown algae and consists of three major fucoidans: F-, U-, G-fucoidan. Many studies have reported multiple biological activities of fucoidan, including anti-coagulant, antivirus, and anti-cancer activities. We previously JJCAM. 2015 September;12 (2):87-93

Immune Efficacy and Safety of Fucoidan Extracted from Gagome Kombu <i>(Kjellmaniella crassifolia)</i> in Healthy Japanese Subjects