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The Serum Lipid Lowering Effect of Rugosa Rose Petal Extract Rich in Polyphenols in Adults with High Serum Triglyceride Takashi YAMAGISHI1,2, Keiji TAKANO1,3, Sumio KONDO4 1 Harunire Bio Institute Ltd. 2 Kitami Institute of Technology 3 DRC Ltd. 4 Medical Corporation Kenshou-kai Fukushima Health Care Center Objective: Hypertriglyceridemia or elevated serum triglyceride (TG) is a leading risk factor for developing atherosclerotic cardiovascular diseases. This clinical study was designed to test the potential of polyphenol-rich extract from Rosa rugosa petals (PE) for improving hypertriglyceridemia and other types of dyslipidemia. Methods: An open-label clinical study was conducted on 19 male and female adult subjects with elevated serum TG (120–399 mg/ dL), who were intervened the study diet containing (in a daily dose) 200 mg of PE once daily for sss4 weeks. The serum levels of TG and cholesterols were measured at baseline and week-4. The efficacy was evaluated by comparing the measurements at these two timepoints. Results: A significant decrease (P < 0.05) in serum TG, as well as in serum total cholesterol and non HDL-cholesterol, and a marginally significant decrease (P = 0.070) in serum LDL-cholesterol were observed, while serum HDL-cholesterol was virtually not changed. The study diet was well tolerated without any untoward side effect. Conclusions: The PE-containing diet appears to have benefits in improving hypertriglyceridemia and hypercholesterolemia.