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The clinical effects of combination chemotherapy with five or six anticancer drugs were investigated on the patients with the advanced cancer which originated mainly from the gastrointestinal tract. The five-drug regimen was found effective in 15 of 21 patients (71%) and the six-drug regimen in 29 of 43 patients (67%). The incidence of the cases which showed favorable clinical responses was higher in the five- and six-drug regimens than in the one-, two- and three-drug regimens. Leukopenia, which occurred in almost half of the patients, was observed more frequently in cases of the six-drug regimen than in cases of the five-drug regimen. Gastrointestinal disturbances were found frequently during and after treatment, and seemed to be aggravated mainly by 5-FU and SP-G in these regimens. The main reasons for the discontinuation of these therapies were firstly leukopenia and secondly gastrointestinal upsets. The cases treated with the five- or six-drug regimen survived only slightly longer than the non-treated. However, there were few remarkable differences in the survival period between the cases of the five- or six-drug regimen and the cases of other regimens.

Clinical Evaluation of Combination Chemotherapy of Solid Tumors with Five or Six Anticancer Drugs