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The effect of anthraquinone sodium anthraquinone-beta-sulfonate anthrarufin anthrone alpha-naphthaquinone lecithin and tannic acid on progestational proliferation produced by progesterone in the rabbit uterus was investigated. Immature rabbits were primed with estradiol-17beta and received simultaneously 2-mg progesterone and 1 of the test compounds in logarithmically graded doses of .001-1000 mg/animal. 24 hours later the animals were sacrificed uteri were excised and the carbonic anhydrase activity of endometrium homogenates were analyzed. Oral anthrarufin inhibited the enzyme activation by progesterone. 1 mg the most effective dose caused a 50% inhibition to the action of 2-mg progesterone (p less than .01). When administered subcutaneously little or no inhibition was observed. These results revealed that of the compounds studied only anthrarfin antagonized the action of progesterone on the rabbit endometrium.

Suppression of Progestational Uterine Mucosal Activity by Anthrarufin