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Isocitric dehydrogenase (ICD) activity of the cerebrospinal fluid was measured on 88 children with various disorders of the central nervous system and on 19 children with non-neurologic diseases, the latter serving as controls. The cerebrospinal fluid ICD activity ranged from 0.9 to 7.7 units with a mean of 4.2±2.1 units in the control series, and was elevated in 7 out of 33 patients with cerebral palsy, in 2 out of 14 with grand mat epilepsy, in one each of cases with viral infection of the central nervous system, cerebrovascular disorder or miscellaneous neurologic disorders, and in none of cases with metabolic errors or infantile spams.

Isocitric Dehydrogenase Activity of the Cerebrospinal Fluid of Children with Neurologic Disorders