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The changes in daily urinary excretion of follicle-stimulating and luteinizing hormones caused by ethinyl-estradiol and conjugated equine estrogens in low doses have been studied with urine samples collected from eight normal menstruat ing women, three normal men, and seven women with abnormal menstrual cycle. Follicle-stimulating hormone (FSH) determinations were done with two separate twenty-four hour urine samples before ethinyl-estradiol (EE) was given; EE was administered in a daily dose of 0.05 mg for four consecutive days and urinary FSH levels were determined in daily urine samples. Two twenty-four-hour urine samples were collected after EE administration was discontinued, and urinary FSH levels were also determined. Conjugated equine estrogens (Premarin) was also given in a daily dose of 0.625 mg for six consecutive days immediately after the EE test; urine specimens were collected daily for luteinizing hormone (LH) determinations. Two twenty-four-hour urine samples were also collected before Premarin was given and basal LH values were obtained. In addition, three normal women received 0.625 mg per day of Premarin early in their menses for six consecutive days, without first applying the EE test for FSH, and LH determina tions were performed on daily urine samples. It was found that 0.05 mg of EE exerted a stimulatory effect on FSH excretion in the normal woman during the second and fourth to fifth days, and that this was statistically different from the response of the normal man and amenorrheal women. Premarin exerted its action principally in amenorrheal women and probably in normal men by increasing LH excretion values on the third to fifth days of its administration. No action was observid in normal women on LH excretion levels by Premarin administration. As a conclusion, it is considered that there is a positive feed-back control mechanism of gonadotropin secretion by the action of estrogen, and the different response pattern of gonadotropin excretion between normal women and those with abnormal menstrual cycle, and between both sexes.

tohoku journal of experimental medicine

Changes in Daily Urinary Excretion of Follicle-stimulating and Luteinizing Hormones Caused by Ethinyl-estradiol and Conjugated Equine Estrogens (Premarin) in Low Doses