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It was demonstrated in both in vivo and in vitro experiments on the renal circulation that dipyridamole produced the potentiation of vascular responses not only to adenosine but also to norepinephrine. The potentiation of these responses was observed when concentrations of dipyridamole were relatively low. As the concentration of dipyridamole was elevated, the potentiation was rather decreased and finally abolished. Furthermore, in in vitro experiments, higher concentrations of dipyridamole blocked the action of norepinephrine. These results cast doubt on the mode of dipyridamole action, which has been interpreted as inhibition of deamination of adenosine.

tohoku journal of experimental medicine

Potentiation of Norepinephrine and Adenosine in the Renal Circulation by 2, 6-Bis (diethanolamino)-4, 8-dipiperidino-pyrimido (5, 4-d) pyrimidine (Dipyridamole&lt;sup&gt;®&lt;/sup&gt;) Treatment (Preliminary Report)