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Hyperpolarization by the vagus stimulation of the quiescent sinus of bullfrog's heart was recorded. The slope and magnitude of hyperpolarization varied with the pattern of vagal impulses. The hyperpolarization became larger with increase in the number of shocks, but after the magnitude of hyperpolarization attained its maximum the potential fell slowly toward the initial level during the stimulation. The optimal interval for the slope and magnitude of hyper

Hyperpolarization of the Quiescent Heart and Inhibition of the Heart Beat by Vagal Impulses