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Per cent of interstitial tissue was measured in liver biopsy specimens of 62 patients with liver cirrhosis. The frequency curve of the per cent of interstitial tissue showed two peaks in 10-19 per cent and in 40-49 per cent, a dell being observed at 30 per cent. Therefore, liver cirrhosis could be classified into two groups, i. e., the group with less than 30 per cent of interstitial tissue and the group with 30 per cent or more of interstitial tissue. Edema, liver enlargement, abnormalities in thymol flocculation test, in cephalin cholesterol flocculation test, and in serum γ-globulin concentration, and deformity of the hepatic veins in hepatic venograms were all significantly more frequently observed in the group with 30 per cent or more of interstitial tissue than in the group with less than 30 per cent of interstitial tissue. There was significant correlation between the per cent of interstitial tissue and the per cent of intrahepatic shunt.

Morphological Classification of Liver Cirrhosis Based upon Measurement of Per Cent of Interstitial Tissue in Liver Biopsy Specimens