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In 1935 Hasegawa et al.1,2) could produce a mutant of tubercle bacilli on culture media containing some chemical drugs such as convallamarin, and in 1937 they attempted similar experiments for the culture of Actinomycetes obtaining an apparently homogeneous cloudy growth of fine granules from 0.1 to 0.5 ƒÊ in diameter.3) These results led them to the conclusion that Actinomycetes was mutated to abnormal fine particles on culture media containing convallamarin. Similar experiments were performed by Takemura4) who obtained the same results. The present experiments have been attempted to know whether it is possible to get a, fine granular growth of Trichophyton in vitro on culture media containing certain chemical drugs.

tohoku journal of experimental medicine

Morphological Observations of the Influence of Some Chemical Drugs on the Growth of Dermatophytes at Concentrations Directly Below the Minimal Inhibitory Concentration