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Though angular stomatitis has been accepted as one of clinical manifestations of ariboflavinosis, still remains obscure the mechanism by which angular stomatitis is brought about. Preceding papers of minel)2)revealed the following results; lysozyme activity showed no significant difference in saliva from subjects with or without ariboflavinosis, but micrococcus lysodeikticus became easily susceptible to lytic action of lysozyme when the microorganism had been cultured on riboflavin-free media. In the present paper I will show that epithelial cells obtained from the lip are more easily susceptible to lytic action of lysozyme in the cases with aribo flavinosis than in those without ariboflavinosis.

Salivary Lysozyme and ts Relation to Angular Stomatitis in Ariboflavinosis