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In 1921, W. Alexander" first pointed out that the blood groups of patients with some diseases show a significant difference in their frequency distribution from those of normal subjects, but in the same year, Buchanan and Higley2) published a report denying such a correlation. Thus, the problem has come into the attention of the researchers in the field. At first, the correlation of the blood groups with malignant tumors was the main theme of study, but no consensus could be arrived at in the conclusions of different authors and the subject was left in the cold for some time till around 1950 it came again into active study, with the advance in statistical research methods, and especially in England and U.S.A. many new works on the problem were published in 1954 through 1956. In recent years, the field of research has been extended from malignant tumors to diseases of other types in general, as fully described in Roberts' review3). The present author mapped out the frequency distribution of the blood groups in 15,744 in-patients accommodated in the national, public and private hospitals in Sendai, relying on the Manual of the International Classification of Diseases, Injuries and Causes of Death4) for classifying the disease types. This frequency distribution of blood groups in the patients was studied in com

Statistical Studies on the Correlation between the ABO-Blood Groups and Some Diseases