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(Received for publication, April 19, 1952) Macrocytic anemia is not uncommonly found among the children with nutritional dystrophy in Hirosaki Area.1) Sato and Wada2) demon strated that macrocytic anemia of Type I (anemia with an increased volume index) was found in the majority of the children who were in a state of nutritional dystrophy and whose livers showed histopatho logical alterations revealed by needle biopsy specimens. On the other hand, Sato,3) one of us, modified the bromsulfalein test for the purpose of detecting such histopathological changes in the liver, as " cloudy swelling," which could not be revealed by means of the ordinary method of bromsulfalein test. In the present paper we shall deal with macrocytic anemia of Type I among children with nutritional dystrophy, from the view point of "liver damage" estimated from results obtained by using Sato's bromsulfalein test.

Macrocytic Anemia and Sato's Bromsulfalein Test in Children with Nutritional Dystrophy